Making and shaping bone

A few years ago we reported that gene mutations which predispose to spina bifida independently diminish bone mass in mice. Now, in collaboration with Prof Philippa Francis-West at King’s College, we’ve completed a wide-ranging invited review of the mechanisms by which bone is made and shaped in the embryo. With over 350 references read and cited, it really is a behemoth of a review!

In it we define critical cellular behaviours which shape skeletal elements during fetal development and raise questions which need to be addressed in future studies. Read all about it here.