By Paola Garcia-Trevijano, UCL Biomedical Sciences

Metabolism’s impact on society is such that the two are in constant interaction.  With this in mind, the Symposium on Food, Culture and Metabolic Health by Metabolism and Society on 16 February brought together a group of academics from several departments in UCL and the Francis Crick Institute.

Complex problems like metabolic disease require interdisciplinary solutions, and fostering such interactions was the goal of this innovative symposium.

Professor Frances Brodsky, Director of the Division of Biosciences, opened the symposium together with Professor Geraint Rees, Dean of the Faculty of Life Sciences.

In addition to three keynote lectures, the day featured short talks followed by a panel focused on fostering potential interdisciplinary collaborations.

The symposium ended on a lighter note with Chris Shipton, a live illustrator, presenting the sketches he put together throughout the day.

At the close of the symposium, Professor David Price, Vice-Provost (Research), announced the creation of a new interdisciplinary Research Domain focused on food and metabolism.

Putting the balance back in diet: the nutritional geometry of metabolic disease

Professor Steve Simpson, academic director of the Charles Perkins Centre of the University of Sydney, showed that the tendency to stick to a constant protein intake contributes to over consumption in fats and carbohydrates, due to the introduction of ultra-processed foods.

A few solutions include intermittent fasting, protein appetite dampening drugs, and surprisingly, a diet low in protein and high in carbohydrates which, despite the associated weight gain, was shown to lead to the healthiest individuals.

Session 1 – Present: where are we now?

In the first session, Dr Paul Chadwick spoke on the importance of developing an efficient way of communicating with different populations affected by metabolic problems. He introduced the behaviour change wheel, which aims to provide a common approach.

Dr Joanne Santini, who presented her work on the effect of arsenic contaminated water on health and the human microbiome, identified the importance of behavioural counselling in preventing and dealing with arsenic poisoning as well as insulin resistance.

Professor Nishi Chaturvedi’s work has shown that different population characteristics suggest different causes behind insulin resistance, highlighting the importance of clinical treatment tailored to different populations.  In addition, linking research in insulin resistance and mitochondrial pathways to tumour research was deemed to be promising, with key connections between the work of Professor Michael Duchen and Dr Mariia Yuneva.

The taste of spoons and other inedible objects

Mark Miodownik, Director of the UCL Institute of Making, gave a keynote presentation on the way different materials influence the experience of eating: gold and chrome taste the most neutral, zinc the sweetest. All these features could be used to not only enhance our enjoyment of food but perhaps reduce the amount of savoury, yet detrimental ingredients (e.g. sugar) that we over-indulge in.

Past: how did we get here?

This session focused on the past to look for guidance on how to shape the future to our benefit.

Evolution in terms of the metabolic network (Dr Markus Rasler) as well as in terms of our adaptation to diet throughout time (Professor Mark Thomas) were considered.

We can also learn from a shorter time frame by following obesity across generations (Professor Rebecca Hardy).

Professor Sue Hamilton discussed the idea of comparing our microbiome to that of the Easter Island population, which thrived with remarkable health and energy on very simple and restricted diets.  Dr Filipe Cabreiro presented his work on the gut microbiome, which the panel felt was an important part of metabolic health, and discussed ways this could be examined from ancient remains to modern humans.
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This, being my first press conference, was a slightly strange, exciting and revealing experience. Sir Paul Nurse, President of the Royal Society and Director of the Francis Crick Institute, was here to take questions on a hotly-anticipated forthcoming Nature paper.

The paper is a genome-wide association study (GWAS) and there is word that this may be the next big thing in genetics research. Paul  gave us a brief back-story.

Ten or fifteen years ago, it was thought only about 1-2% of the human genome was biologically functional, the rest considered to be “junk DNA” with no known function. Recently, however, a lot of evidence has been gathered to suggest that the remaining 98% is doing a lot more.

Sir Paul was predictably asked whether this new research will be a major “breakthrough” in medical genetics. Coolly dismissing the media’s obsession with breakthroughs, he replied that he preferred to describe it as “just another brick in the wall” –  he must be a Pink Floyd fan.

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