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Janssen UCL Medicinal Personalization



JUMP Project

New stratification strategies offer exciting opportunities to further personalize treatment, providing important new avenues to target resources. The JUMP project represented a TSB-funded inter-disciplinary, collaboration between the UCL School of Management, UCLH, The Royal Free, and Janssen Diagnostics to develop such a strategy involving the introduction of a rapid turnaround diagnostics service for Hepatitis C patients in the NHS. The service involves Hep C patients coming in to have their blood samples taken and have a consultation on the basis of their blood results, during a single appointment slot. Clinicians using this services are able to make more informed treatment decisions because they have access to current diagnostics information on a patient’s viral load count that is valuable in stratifying patients according to their response to (triple therapy) treatment. This website provides the public access to the JUMP project tools produced by members of the research group of Simcha Jong, Assistant Professor, and Programme Director of the Healthcare Management Initiative at the UCL School of Management. These tools will allow users to map the potential economic, clinical, and logistical issues associated with the implementation of rapid turnaround diagnostics services. The downloadable tools will be helpful for healthcare providers to:

  • Calculate savings associated the implementation of rapid turnaround testing for individual Hep C treatment centers based on the specific characteristics of individual centers and their patient populations.
  • Run scenarios to assess potential savings associated with other changes to the management of Hep C clinics.
  • Assess changes in patient waiting times and flows associated with the implementation of rapid turnaround testing based on specific characteristics of clinic and served patient population.


Downloadable tools:

Valuation tool for the assessment of scenarios involving changes to treatment protocol/care pathway/patient mix

Valuation tool developed based on data on Hep C care at the London Royal Free Hospital as well as national demographic data on Hep C patients to account for the location of patients with different genotypes, stages of disease, treatment status, etc. A clinician or administrator of a Hepatitis C clinic will be able to use the tool both based on data on patient numbers, patient characteristics, diagnostic and drug therapies prescribed, pathology lab set-up and turnaround times for processing viral load samples, as well as costs associated with clinic operation. If the user cannot supply specific data points, these will be automatically estimated by the tool.

Tool User Guide
Case study 1:

Assessing the impact of the implementation of rapid turnaround testing in Hep C care at the Royal Free.

Case study 2:

Customising assessments of the implementation of rapid turnaround testing according to characteristics of individual Hep C treatment centres.

Simulation tool to estimate patient waiting times and resource uses in the management of Hep C treatment centers

This tool supplements the cost-effectiveness analysis we presented above by focusing on the operation side of HCV clinic management. The tool models the impact of changes in a treatment pathway, illustrating these in a clear, visually engaging manner.

SIMUL8 User Guide