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Who’s Who in UK Science Policy Prof Mark Walport – Director of the Wellcome Trust

By key_concepts_team, on 12 October 2009

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The Wellcome Trust was established in 1936 to improve human and aminal health in the UK through research, and is currently the largest charity in the UK. It spends over £600 million per year to support science and as a consequence is the UK’s largest non-governmental source fund of funds for biomedical research. It therefore follows that as director of the Wellcome, Prof Mark Walport has a significant influence on the direction of UK science policy. He was appointed in 2003 and was previously a Professor of Medicine at Imperial College London and their Head of the Division of Medicine. Before his appointment as the director he was a governor of the Wellcome Trust.

Short Stories about Genetics

By ucrhrmi, on 3 October 2009

Few discussions of the impact of new genetic technologies continue for too long without mention of Aldous Huxley’s Brave New World.  Huxley’s dystopian vision of a world shaped by biological science has inspired many critiques of genetics. Yet it was published in 1932, two decades before Watson and Crick’s discovery of the structure of DNA.  A new project by the ESRC Genomics Forum attempts to update our visions of the genetic future, with a series of short stories “inspired by genetics”. They’re all freely available, and cover a range of issues around genetics.

science 2008-2009: 16: Obama

By Jon Agar, on 2 October 2009

President George W. Bush was frequently criticised for his policies affecting science. The values of the conservative Christian right had guided Bush’s 2001 decision to stop federal funding of research on new embryonic stem cell lines. Since then the United States had been overtaken by countries that were more permissive in this specific biomedical field: Singapore, the United Kingdom, Israel, China and Australia.  Bush’s administration was accused of conducting a ‘war on science’, with allegations of interference and the re-writing of evidence (Mooney 2005), and of a ‘failure to deal with the risks of nuclear proliferation’, walking away, for example, from the Nuclear Non-Proliferation Treaty.

‘Many researchers, of all political stripes, are deeply troubled by what they regard as the dysfunctional relationship between science and the outgoing Bush administration’, noted a Nature editorial in January 2008. The Democrat candidate, Barack Obama, was comfortable supporting investment in science and unambiguously backing the teaching of evolution by natural selection. The Republican ticket, John McCain and his running mate Sarah Palin, was split with the two representing wildly different constituencies. Palin’s comments during the campaign – hedging her views on whether climate change is being caused by humans, strongly opposing embryonic stem-cell research, promising to cut funding, as she said in debate, for “fruit fly research in Paris, France. Can you believe that?” – threatened to overshadow McCain’s stance.  

However, a science debate, pushed for by a campaign given coverage by Science and Nature, never materialised. Science, in the end, was not a crucial issue for the 2008 election.

On winning the election, president-elect Obama began appointing key officials. In December, the post of secratary of the Department of Energy, with a seat at the cabinet, was given to a scientist, the physicist Steven Chu, who was director of the Lawrence Berkeley National Laboratory and a Nobel prize winner. In January 2009, Obama appointed his science adviser. John Holdren’s career was varied, in all the right places: a physicist, with experience as an engineer at Lockheed Missiles and Space Company, fusion research at the Lawrence Livermore National Laboratory, anti-nuclear proliferation work with the Pugwash organisation, and now a Harvard environmental policy expert in charge of the Woods Hole Research Center. Other Obama picks included Harold Varmus, who had directed the National Institutes of Health, and Eric Lander, one of the leaders of the Human Genome Project.

Early in his presidency, in March 2009, Barack Obama used an executive order to overturn Bush’s restrictions on federally funded stem-cell research, ‘issued a memo directing [John Holdren] to ensure scientific integrity in government decision-making’, and budgeted for big increases in science funding.

science 2008-2009: 15: Europe

By Jon Agar, on 2 October 2009

Many news stories concerning the sciences in European countries reveal continuities in theme that stretch back far into the twentieth century.

The Russian Academy of Sciences has continued to have a close but difficult relationship with the supreme political powers of the nation. The appointment of Vladimir Putin’s favourite for president of the Academy, Mikhail Kovalchuk, controller of the purse-strings of a $7 billion nanotechnology initiative, was being held up by Academicians in 2008. They nevertheless chose to retain Yuri Osipov, a 71-year-old mathematician, a probable placeholder for Kovalchuk, as president of the Academy, rather than elect Vladimir Fortov, a modernising physicist who did not have Putin’s support. Fortov promised the introduction of international peer review and open competition for funding. Putin, on the other hand, doubled Academicians’ salaries.

In France, too, the tensions were between the centralised institutions of science and the movements for political reform. President Nicolas Sarkozy pushed to make universities more autonomous, able to set their own budgets and pursue their own research programmes. In a closely related move, Sarkozy also wanted to complete reform the CNRS, the body in France that both funds and performs, in its constituent laboratories, most French research. The idea was that CNRS would become more like a research council, a funder rather than a performer of science. In effect, these reforms would make the French system much more like the British system. This direction was, for Sarkozy’s critics on the left, enough evidence that an Anglo-American liberalisation, perhaps privatisation, agenda was being followed. University staff went on strike in 2009, while CNRS scientists, in a campaign co-ordinated by Claire Lemercier, invaded CNRS’s Paris headquarters in June 2008 in protest against the plan to break up CNRS into six parts.

Meanwhile, the European Research Council was set up in February 2007. The European Research Council is rather like a National Science Foundation for the European Union (plus Israel). It distributes about a billion euros a year. Not new money, but rather old science funding money now allocated at a European rather than at a national level. The Council is an agency, separate from, but not entirely legally independent of, the European Commission. (Nature in July 2009 backed arguments calling for the European Research Council to be fully autonomous).

The difference, at least from the perspective of scientists in some European Union nations, was the commitment to award grants on the basis of international peer review rather than according to political choices. The selection process was designed to be blind to national origin of the research proposals. Nevertheless, in the first round of 300 grants, in 2008, the allocations followed traditional geographies of scientific strengths, with the United Kingdom doing particularly well (58) followed by France (39), Germany (33), Italy (26), the Netherlands (26), Spain (24) and Israel (24). In comparison Bulgaria and the Czech Republic only received one grant each.

science 2008-2009: 14: China

By Jon Agar, on 2 October 2009

Who was a typical scientist in 2009? A case can be made for it being a technician working in a contract research organisation in China.

The numbers are certainly impressive. In 1949, China had 50,000 people that could be broadly categorised as working in science and technology in a total population of half a billion. By 1985, just before Deng Xiaoping relaunched Chinese science, the figures were 10 million in a billion. In 2006 China devoted 1.6% of its GDP to research and development, and its leaders announced a target of raising this figure to 2.5%. (Reaching this figure would mean that China was spending proportionately more on research and development that any European nation, would be roughly equal to the United States, and was approaching the scale of Japan’s investment.) Furthermore, with the increase in funds, the output of Chinese science was also increasing: second only to the United States in overall number of journal articles published, growing from 1% of the world’s total in 1994 to 6% in 2006. Like India, China has launched high profile space missions, including a spacewalk in 2008.

Such growth is revealing some interesting issues and tensions.

Starting with journals, large numbers of papers is not the same as large numbers of good papers. ‘the average impact’ of Chinese articles, noted journalist David Cyranoski in Nature, ‘was below average even in China’s strongest fields of materials science, physics and chemistry’. Furthermore, researchers at the best institutions are encouraged to publish in journals listed in the Science Citation Index. These are predominantly English-language journals. An ‘unintended consequence’, notes science policy analyst Lan Xue, has been to ‘threaten to obviate the roughly 8,000 national scientific journals published in Chinese’.

Indeed, there is an unresolved tensio between western and native sciences. Lan Xue cites the case of earthquake prediction. In the 1960s and 1970s ‘China set up a network of popular earthquake-prediction stations, using simple instruments and local knowledge’. This network was decommissioned in favour of a high-tech system. But when the new system failed to predict the Sichuan earthwuake of 2008, it was claimed that the indigenous stations would have. Lan Xue argues that a one-science-fits-all approach should be rejected: ‘one should tolerate or even encourage such indigenous research efforts in developing countries even if they do not fit the recognized international scientific paradigm’.

The tension is not just with indigenous traditional but also with the brute political fact that China has a slow-moving one-party system of rule overseeing a fast-moving economy including an expanding science sector. In 2009, the editors of Nature, reflecting on the obstacles in the way of setting up a national stem-cell science society, urged the political authorities to ease the severe restrictions on forming groups. The problem was that the Chinese authorities, in the absence of democratic legitimation, had an ‘aversion to congregations’, seeing groups, not least Falun Gong, as the seeds of political challenge. Furthermore, the established scientific organisations are more concerned about the maintenance of hierarchy and status than the encouragement of critical debate. ‘Most of the current learned societies do not function well’, ran the Nature editorial, ‘Annual meetings are often a matter of pomp, with elite researchers showing up to swagger about and form cliques based on pedigree rather than scientific views… Constructive criticism is more likely [to] be taken as grounds for breaking off relations than as insightful advice’.

Political sensitivities also shape international relations. Environmental research, especially in Beijing’s Olympic year of 2008, drew the watchful eye of political authorities. Two new laws, Measures for the Administration of Foreign-related Meteorological Sounding and Information (January 2008) and Measures Governing the Survey and Mapping in China by Foreign Organizations and Individuals (March 2008) were introduced to clamp down on unauthorised release of data. Collaborative projects have had their field stations in Yunnan dismantled; geologists working in the sensitive Tibet and Xinjiang region objected to the use of GPS. Projects, to be approvedm had to be seen to be ‘in China’s best interest’. But these laws were also about makings sure that Chinese science benefited from scientific research conducted within Chinese borders: hence the insistence on a demonstrable “equitable partnership” before approval.

Nor, of course, is China immune from the forces of globalisation. It trades with the world, manufacturing much of its goods. Its people travel. China is therefore, by necessity, part of the international science-based networks of organisation that are the infrastructure that make the global world of travel and trade. For example, the network of international disease notification and control has tested the Chinese authorities several times in recent years. The emergence of a new viral disease, Sudden Acute Respiratory Syndrome (SARS) in 2003 revealed problems with Chinese healthcare and how it communicated information with the rest of the world. The outbreak eventually stung the authorities into action: “After SARS they started spending“.

The Chinese government has a stated aim of making China a place of predominantly home-grown innovation. (Only a minuscule proportion of new drugs approved in China, for example, are discovered there.) China aims to be among the top five nations in areas such as producing new patents. ‘These are uncomfortable goals for China’, argues David Cyranoski, noting the industrial non-government source of most research and development funds, ‘because, unlike space research, they are more difficult to mandate from the top down’. Indeed it is science deriving from the working world of Chinese and multinational industries that has taken off, to such an extent that complaints such as the following (from a German academic in 2008 with extensive knowledge of working in Chinese science): “Making money has become the major attraction in China and this has severe consequences at the university level: basic research is not considered as important and attractive as it had been”.

Let’s look in more detail at the multinationals’ activities in China. Motorola set up ‘the first major foreign corporate research and development centre on Chinese soil’ only in 1993. ‘In 1997, China had fewer than 50 research centers that were managed by multinational corporations, by mid-2004, there were more than 600’ (see p.210). What are they doing there are why? First, there are companies, such as Pfizer, Roche and Eli Lilly, which set up offices in the Zhangjiang Hi-Tech Park in Shanghai, which are attracted the burgeoning number of contract research organisations ‘selling almost every service a pharmaceutical or biotech company could want, including teh production of active ingredients, genomics, analytical and combinatorial chemistry, and preclinical toxicology testing’. Cheap clinical trials are a particular draw, costing between one-fifth and one-half the cost of running one in the United States. Eli Lilly’s Shanghai office did no science itself, but put together chains of contract research organizations. The cost and flexibility were the over-riding interests.

Second, companies have an eye on China itself as a growing and lucrative market, especially for drugs and therapies. Locating a research and development centre in China then is done for tactical purposes rather than in any expectation of new worthwhile discoveries. A research branch ‘helps build connections with regulatory agencies’ and facilitates ‘access to a market that some analysts predict will be the world’s second largest after the United States by 2020’.

Third, some companies are intent on tapping local resources. These resources can be human knowledge and skills: GlaxoSmithKline, for example, have chosen to locate their “R&D China” subsidiary next to the Shanghai Institutes for Biological Sciences rather than across the city in the Zhangjiang Hi-Tech Park because the company wanted “hard-core science” not “services”. Nevertheless a secondary justification, given by Jingwu Zang, the leader of GSK’s R&D China, was ‘the benefits of being able to transition drugs to a growing Chinese market more easily’.

Of course, expensive Western-style healthcare is not a unmitigated boon. Parts of China are booming, but other parts suffer desparate poverty. The uneven development within China is directly mirrored in a map of Chinese science: overwhelmingly located in Eastern hotspots: Beijing, Shanghai, and Guangdong.  This final tension show no signs of declining in force. An nation (and China is not alone) that can aim to ‘send a satellite to Mars but not solve the most basic problems that threaten millions of lives in the developing world’ can expect uncomfortable questions.

science 2008-2009: 13: India

By Jon Agar, on 1 October 2009

Independent India has long had a technocratic streak. The relationship between Nehru and elite physicists (including select Westerners such as Patrick Blackett) was strong. One result was a nuclear programme that culminated in the first Indian nuclear test in 1974. In 1958, Nehru had asked the father of the Indian bomb, physicist Homi Jehangir Bhabha, to draft a new science policy. “the gap between the advanced and backward countries has widened more and more”, the motion that passed the Indian Parliament stated, “It is only by adopting the most vigorous measures and by putting forward out utmost effort into the development of science that we can bridge the gap” (quoted here). An outcome was another techno-scientific project whose primary output was, at least initially, national prestige: a space programme. An Indian satellite was launched from Kerala in 1980.

Following economic liberalisation in 1991, India has been sending more and more students to train abroad, funded since 2001 by government loans on easy terms. In 2002 ‘India surpassed China as the largest exporter of graduate students to the United States’ (p.79). Attractive polcies encouraged the students to return, bringing skills home.

Furthermore, this accumulation of skills has encouraged science-based corporations to set up laboratories. India’s science policy leaders were bullishly optimistic. ‘More than 100 global companies…have established R&D centres in India in the past 5 years, and more are coming’, noted Raghunath Mashelkar, director general of India’s Council for Scientific and Industrial Research, speaking in Science in 2005, ‘As I see it from my perch in India’s science and technology leadership, if India plays its cards right, it can become by 2020 the world’s number-one knowledge production center’.

And the prestige projects have benefited too. Between 1999 and 2003, under the leadership of Krishnaswamy Kasturirangan, a coalition of elite scientists and politicians drew up proposals for Indian moon missions. ‘Their stated goals’, notes Subhadra Menon, ‘were to expand human knowledge, and to challenge India to go beyond geostationary orbit, thereby potentially attracting young talent to the space sciences and into the country’s space programme’. The moon probe Chandrayaan-I, carrying eleven payloads (five Indian, two from NASA, three from the European Space Agency, and one from Bulgaria) observed the moon in 2008 and 2009. In September 2009, just before expiring, it reported the presence of minute, but significant, quantities of water.

The Indian bureaucracy is also becoming far more protective of the country’s genetic riches. For example, in 2008 a colllaboration between the Indian Ashoka Trust for Research in Ecology and the Environment and the American Illinois Natural History Survey stalled because of official complaints about biopiracy. A researcher for the Askoka Trust said: “We have to send the specimens abroad for identification as we do not have the expertise at home”, while the senior official at the National Biodiversity Authority responded: “exporting 200,000 specimens is not permissible”. Exporting photographs would be fine, but not gene-rich specimens.